The Ayurvedic Supplement for Longevity, Relaxation, and Renewal

The Benefits of Calorie Restriction

Resveratrol is one of the few natural compounds that mimic the health and longevity benefits of calorie restriction.

And what are those benefits? Eating 20 to 30 percent fewer calories has been found to be one of the most powerful health- and longevity-promoting interventions.

In an early study with monkeys, one test group was fed an unrestrained diet while the other was fed 30 percent fewer calories than normal.

They were followed for 20 years, and the researchers found that 30 percent of the unrestricted eaters died of age-related causes while only 13 percent of the calorie-restricted group died from age-related causes.

Follow up studies have linked calorie restriction to better immunity, blood sugar regulation, cholesterol, weight, blood pressure, and immunity.

Resveratrol Mimics Calorie Restriction

Resveratrol is an antioxidant-rich, polyphenolic compound found in foods such as mulberries, peanuts, Japanese knotweed, grapes, and red wine—which are all considered hormetins, meaning they endure environmental stressors such as drought and heat. Hormetics respond to their harsh conditions by manufacturing powerful and protective antioxidants needed for their survival. When these plants transfer their protective nutrients like resveratrol to humans, it is called xenohormesis.

Resveratrol is one of the most effective and powerful hormetins.

In a 2011 study, published in the journal Cell Metabolism, 11 obese humans were given 150 mg of a resveratrol extract called resVida (the same formula used in LifeSpa’s Resveratrol Boost) for 30 days. This was a randomized, double blind, placebo-controlled, cross-over study.

The results were remarkable. Longevity and health span markers, such as increased insulin sensitivity, AMP-activated protein kinase (AMPK), which is an enzymes that triggers the production of body’s energy manufacturing sites in the mitochondria, and sirtuins (SIRT1)—which are proteins that act as cellular and DNA protectors linked to health and longevity—were found and replicated.

Resveratrol was identified as the most potent activator of SIRT1. Subsequent research has found that resveratrol may not activate SIRT1 directly, but rather exert its effects on SIRT1 through activation of AMPK.

In the 2011 study, researchers found that energy production from cellular mitochondria increased, while blood sugar, triglycerides, inflammation, fatty liver, and obesity were improved. The study concluded that “30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.”

LifeSpa’s Resveratrol Boost Goes Beyond Life Span to Health Span

Resveratrol Boost is a premium nutritional supplement made to support longevity, the cardiovascular system, healthy blood pressure, immunity, estrogen metabolism, and hormonal balance. This product contains patented resVida plant-derived trans-resveratrol, tested for both purity and potency.

Hormonal Balance

Estradiol has the strongest estrogenic effects in the human body. It is slightly more potent than estrone and significantly more potent than estriol.

Problems arise in both males and females when estrogen (particularly estradiol) levels are too high or too low. This can lead to irregular estrogen levels, low sex drive, weakened immune function, irritability, fatigue, weight gain, and more.(1,2,3)

Research on resveratrol has shown it acts as a modulator of estrogenic hormone production by regulating estrogen receptor binding.(4)

In turn, this modifies luteinizing hormone and follicle stimulating hormone levels, which ultimately regulate the production of testosterone. It has also been demonstrated that, in males, resveratrol increases sperm output and supports sexual health.(5) Moreover, grape seed extract found in Resveratrol Boost contains a highly potent class of antioxidants—called proanthocyanidins— which have been shown to support healthy blood pressure and blood flow by expanding blood vessels.(6,7)

Immunity, Heart and Circulation

We also included green tea leaf extract, providing catechins that support your cardiovascular system and immunity by acting on reactive oxygen species in the body.(8,9)

Resveratrol Boost is rounded out with the plant polyphenol quercetin. This potent antioxidant appears to work synergistically with resveratrol to support blood lipid levels, blood flow, and also promote heart health.(10,11)

Resveratrol Boost Supplementation

In summary, research suggests the ingredients found in Resveratrol Boost work to support:
Longevity markers SIRT1 and AMPK
Healthy metabolism, weight, blood sugar, and blood pressure
Immunity
Healthy estrogen metabolism
Healthy blood lipid levels and vascular function
Mood and well-being
Energy levels
Antioxidant activity throughout the body
Sexual health in males

Try Resveratrol Boost

Resveratrol Boost is a premium nutritional supplement made to support the cardiovascular system, healthy blood pressure, immunity, estrogen metabolism, and hormonal balance.

References:

1. Verthelyi, D. (2001). Sex hormones as immunomodulators in health and disease. International immunopharmacology, 1(6), 983-993.

2. Toppari, J., Larsen, J. C., Christiansen, P., Giwercman, A., Grandjean, P., Guillette Jr, L. J., … & Leffers, H. (1996). Male reproductive health and environmental xenoestrogens. Environmental health perspectives, 104(Suppl 4), 741.

3. Rohr, U. D. (2002). The impact of testosterone imbalance on depression and women’s health. Maturitas, 41, 25-46.

4. Bowers, J. L., Tyulmenkov, V. V., Jernigan, S. C., & Klinge, C. M. (2000). Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β 1. Endocrinology, 141(10), 3657-3667.

5. Shin, S., Jeon, J. H., Park, D., Jang, M. J., Choi, J. H., Choi, B. H., … & Kim, Y. B. (2008). trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo. Archives of pharmacal research, 31(1), 83-87.

6. Bagchi, D., Garg, A., Krohn, R. L., Bagchi, M., Bagchi, D. J., Balmoori, J., & Stohs, S. J. (1998). Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. General Pharmacology: The Vascular System, 30(5), 771-776.

7. Barona, J., Aristizabal, J. C., Blesso, C. N., Volek, J. S., & Fernandez, M. L. (2012). Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. The Journal of nutrition, 142(9), 1626-1632.

8. Shankar, S., Ganapathy, S., Hingorani, S. R., & Srivastava, R. K. (2007). EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Frontiers in bioscience: a journal and virtual library, 13, 440-452.

9. Valcic, S., Muders, A., Jacobsen, N. E., Liebler, D. C., & Timmermann, B. N. (1999). Antioxidant chemistry of green tea catechins. Identification of products of the reaction of (−)-epigallocatechin gallate with peroxyl radicals. Chemical research in toxicology, 12(4), 382-386.

10. Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. Eur J Pharmacol. 2008;582(2-3):325-37.

11. Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Bio Pharm. 2000;60(10):1539-48.