New Science on Ashwagandha: Ayurveda’s Top Herb for Longevity

New Science on Ashwagandha: Ayurveda’s Top Herb for Longevity

In This Article

Ashwagandha Mimics Longevity Strategy 

Ashwagandha is one of most revered adaptogenic herbs in the world, termed a rasayana in Ayurveda. Emerging research finds withaferin A, a main constituent of ashwagandha, supports prevention of age-related protein damage and healthy weight.  

A decade of research on these pathways has been performed on the blood sugar drug metformin. Ashwagandha’s withaferin A has been shown to mimic metformin’s longevity properties. 

Note: Ashwagandha is not a replacement for metformin. If you are taking metformin, or any other prescribed medication, do not discontinue use and check with your doctor before making any changes to your regimen. 

Lengthen Lifespan with AMPK + mTOR 

Based on numerous studies over the past decade on metformin’s ability to lengthen lifespan, a massive study called the TAME Trial (Targeting Aging with Metformin) is underway to determine if metformin can be prescribed as a longevity (as well as a blood sugar) agent.6 

Researchers are investigating possible mechanisms for metformin’s effectiveness.  The cellular enzyme AMPK (adenosine monophosphate-activated protein), considered one of the body’s master regulators of cell metabolism, is responsible for metformin’s ability to increase insulin sensitivity, support healthy blood sugar, and increase longevity.1,7  

AMPK has also been shown to sustain autophagy (cellular nutrient conservation and repair) while inhibiting mTOR (mammalian target of rapamycin), linked to cellular growth, obesity, and higher levels of the growth hormone insulin.5,7  

Ashwagandha + AMPK Activation 


In one study, an artificial intelligence mainframe scanned over 800 natural compounds to evaluate their ability to maintain these slower aging signaling pathways—and ashwagandha was at the top of the list.8 

The active constituent in ashwagandha, withaferin A, has also been shown to mimic metformin in increasing AMPK and inhibiting mTOR—the two major pathways linked to longevity.2-4  

One of the major causes of aging is breakdown of protein in the body. This is seen commonly with aging when the protein collagen breaks down and the skin becomes thin and wrinkled. 

Ashwagandha has been shown to activate a protein cleanup network that removes damaged proteins from the body through autophagy.9,10 

Autophagy, activated by increased AMPK and inhibited mTOR, is seen from both metformin and ashwagandha. Studies on autophagy recently won the Nobel Prize as the body’s housecleaning and repair process that spontaneously happens during periods of starvation, calorie restriction, and fasting.11 

We recommend "Intermittent Fasting, Autophagy + Ayurveda"

Ashwagandha for Longevity + Healthy Weight 

In mice, ashwagandha’s withaferin A demonstrated a 39% reduction of age-related protein damage in the spinal cord, and a 60% reduction in age-related protein damage in motor neuron cells—the cells that transmit movement signals from the brain, through the spinal cord, and to the muscles. 

In the same study, mice with age-related protein breakdown in their nervous systems were supplemented with withaferin A and their lives were extended by 5.6%.12 

Weight gain is also associated with breakdown of proteins in the body. In one study, overweight mice were fed a high-fat diet. The group that was supplemented with withaferin A saw a significant reduction in weight. Compared to the control group, there was a 23% reduction in weight and fat mass, while the placebo group saw no weight loss.13 

The mechanism for weight reduction was reported to be that the group given withaferin A naturally ate 60% less food. This was due to an increase in the appetite suppression hormone leptin, which made them feel full from much less food. Weight gain has been linked to a decrease or insensitivity to leptin. 

Withaferin A (ashwagandha) has been shown to boost leptin levels and leptin sensitivity.13 It does this by gobbling up damaged proteins (autophagy), which helps maintain normal signaling pathways.5 

Have you tried ashwagandha for longevity, weight balancing, or other benefits? What have you noticed? 

We recommend "Get The Energy You Need to Sleep with Ashwagandha"

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Dr. John



2 thoughts on “New Science on Ashwagandha: Ayurveda’s Top Herb for Longevity”

  1. Longevity means also better health overall? Modern unregulated industry is making us more and more sick. Who profits to? This should be in every newspaper in the world on first page, but you know who owns the media. Ops, it’s old news, purposely hidden under the rag. “They” didn’t wanted to follow up this “controversial “ route. Bad for them and stock market.
    “In the famous Swiss study published in 1989, chelation therapy was found to have a profoundly positive preventative effect on cancer:
    Mortality from cancer was reduced 90% during an 18-year follow up of 59 patients treated with calcium-EDTA. Only one of 59 treated patients died of cancer while 30 of 172 non-treated control subjects died of cancer. Observations relate only to long-term prevention of death from malignant disease, if chelation therapy is begun before clinical evidence of cancer occurs. Control and treated patients lived in the same neighborhood, adjacent to a heavily traveled highway in a small Swiss city.  Both groups were exposed to the same amount of lead from automobile exhaust, industrial pollution and other carcinogens. Exposure to carcinogens was no greater for the studied population than exists in most other metropolitan areas throughout the world. Statistical analysis showed EDTA chelation therapy to be the only significant difference between controls and treated patients to explain the marked reduction in cancer mortality.
    – Blumer W, Cranton E. Ninety Percent Reduction in Cancer Mortality after Chelation Therapy With EDTA. Journal of Advancement in Medicine. Spring/Summer 1989”

    Nowadays EDTA Lead Chelation is with Magnesium EDTA.
    EDTA cannot however chelate mercury. DMSA and DMPS, the chemicals which work intravenously to chelate mercury, are not currently approved for use by the FDA.
    They are all to old remedies. Nothing new in long time. Just something to think about.
    FYI, now instead of Lead is used Cadmium. And MTBE.
    From Internet:
    MTBE in Fuels
    2013 status update
    In 2005, Congress passed the Energy Policy Act that removed the oxygenate requirement for reformulated gasoline (RFG). At the same time, Congress also instituted a renewable fuel standard. In response, refiners made a wholesale switch removing MTBE and blending fuel with ethanol. According to EPA’s RFG Survey Data, MTBE has not been used in significant quantities in RFG areas since 2005. A similar decrease in MTBE use has also been observed in conventional gasoline areas.
    What is MTBE?
    MTBE(methyl tertiary-butyl ether) is a chemical compound that is manufactured by the chemical reaction of methanol and isobutylene. MTBE is produced in very large quantities (over 200,000 barrels per day in the U.S. in 1999) and is almost exclusively used as a fuel additive in motor gasoline. It is one of a group of chemicals commonly known as “oxygenates” because they raise the oxygen content of gasoline. At room temperature, MTBE is a volatile, flammable and colorless liquid that dissolves rather easily in water.

    • Chelation therapy can be speeded up 10X, 20X,30X time’s harmlessly. But, it can’t be patented. People lost knowledge in TV century.


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